Treatment Resistant Depression

Up to two thirds of people with Major Depression do not respond to the first treatment plan after diagnosis. Depression treatments are considered resistant when at least two trials of antidepressants from different pharmaceutical classes do not achieve remission.
It’s been found that patients who require multiple treatment steps have higher relapse rates. 10 to 30 percent of patients report the continuous experience of self harming behavior, suicidal ideation, and poor quality of life.
Depression is not an uncommon disorder in the United states, with up to 13 percent of people experiencing lifelong symptoms. On average, consistent depressive moods will emerge around the age of 30, with a higher prevalence in women, caucasians, and Native Americans. Of those suffering, only 60 percent receive treatment. Primary care physicians will only diagnose one third to half of their patients experiencing depression.
Before treatment resistance is identified, physicians generally assess the patient’s consistency in following the treatment plan. It’s been found that up to 50 percent of all patients do not follow a consistent routine in taking the prescribed medication. Other psychiatric and physical risk factors can also complicate treatment of underlying depression, including:
Furthermore, the likelihood of developing Major Depression can be increased by up to 67% after being diagnosed with a serious medical condition such as diabetes, cancer, Parkinson’s, or epilepsy, to name a few examples. Treatment approaches for Major Depression involve CBT or interpersonal psychotherapy, antidepressant medication, and electroconvulsive therapy when the first two approaches are ineffective.

While Treatment Resistant Depression may seem to be inherently discouraging on the road to recovery, there is research being done to identify additional treatment methods. Over the last two decades, studies have come out demonstrating the efficacy of ketamine to quickly and sustainably treat depressive symptoms. While there are still side effects to this treatment option, it is garnering attention through promising research studies and continues to offer hope. 

Those who cannot achieve remission through several antidepressant treatments suffer the injurious symptoms of Major Depression with no end in sight. This does not have to be the only outcome of Treatment Resistant Depression. To take the first step on the path towards real recovery, seek treatment through ketamine infusion therapy. Reach out to a trusted physician today to learn more.